Saline Systems Volume 2
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 ReviewPost-genomics of the model haloarchaeon Halobacterium sp. NRC-1Shiladitya DasSarma1 , Brian R Berquist1 , James A Coker1 , Priya DasSarma1 and Jochen A Müller2  1University of Maryland Biotechnology Institute, Center of Marine Biotechnology, 701 E. Pratt Street, Suite 236, Baltimore, MD 21202, USA 2Department of Biology, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA author email corresponding author email
Saline Systems 2006,
2:3doi:10.1186/1746-1448-2-3 Abstract
Halobacteriumsp. NRC-1 is an extremely halophilic archaeon that is easily cultured and genetically tractable. Since its genome sequence was completed in 2000, a combination of genetic, transcriptomic, proteomic, and bioinformatic approaches have provided insights into both its extremophilic lifestyle as well as fundamental cellular processes common to all life forms. Here, we review post-genomic research on this archaeon, including investigations of DNA replication and repair systems, phototrophic, anaerobic, and other physiological capabilities, acidity of the proteome for function at high salinity, and role of lateral gene transfer in its evolution. |