|
Selected gene homologies relevant to this work |
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| Halobacterium |
Bacteria |
S. cerevisiae |
S. pombe |
human |
Function |
|
|
|||||
| rad21 |
RAD271 |
rad21 |
FEN-11 |
structure-specific endunuclease makes 3' incision in base excision repair |
|
| rad3a, rad3b |
RAD3 |
rad15 |
XPD |
5' to 3' helicase |
|
| rad25a, rad25b |
RAD25 |
XPB |
3' to 5' helicase |
||
| RAD2 |
rad13 |
XPG |
makes 3' incision in eukaryotic NER |
||
| eif4a |
RAD1 |
rad16 |
XPF |
makes 5' incision in eukaryotic NER (with RAD10/ERCC1) |
|
| uvrA, uvrB, uvrC, uvrD |
uvrA, uvrB, uvrC, uvrD |
recognition, incision and removal of damaged DNA in bacterial NER |
|||
|
Notes 1 S. cerevisiae RAD2/human XPG belongs to the same multigene family as S. cerevisiae RAD27/FEN-1 but the Halobacterium sp. NRC-1homolog, rad2, is more closely related to RAD27/FEN-1. There is no other homolog in Halobacterium sp. NRC-1. | |||||
Crowley et al. Saline Systems 2006 2:11 doi:10.1186/1746-1448-2-11 |
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